Tag: NSD2

MS159 is a First-In-class NSD2 PROTAC degrader for Multiple Myeloma Research

Proteolytic targeting chimera (PROTAC) is a heterobifunctional small molecule, including two active domains, and a linker. Importantly, it can remove specific unwanted proteins. PROTAC is a technology based on the ligand binding of TAP and then the degradation of TAP. PROTAC provides an alternative approach to those so-called non-druggable...

MR837 is an Inhibitor of NSD2-PWWP1

NSD2 (nuclear receptor-binding SET domain-containing 2) is a protein lysine methyltransferase. It belongs to the NSD family, which also includes NSD1 and NSD3, and that predominantly mono- and dimethylates lysine 36 of histone 3 (H3K36). NSD2 is an oncoprotein that is aberrantly expressed, amplified, or somatically mutated in multiple...