NSD2 (nuclear receptor-binding SET domain-containing 2) is a protein lysine methyltransferase. It belongs to the NSD family, which also includes NSD1 and NSD3, and that predominantly mono- and dimethylates lysine 36 of histone 3 (H3K36). NSD2 is an oncoprotein that is aberrantly expressed, amplified, or somatically mutated in multiple...