Reversin 121, a P-glycoprotein Inhibitor, Reverses P-glycoprotein-Mediated Multidrug Resistance
Nowadays, how to overcome the resistance of tumor cells to multiple drugs is still a serious problem. Various mechanisms can cause Multidrug resistance (MDR), including cell cycle alterations, increased repair of damaged DNA and activation of detoxifying systems. Noticeably, ATP-binding cassette proteins are the most significant factor in drug...
Rosabulin is a Potent Microtubule Inhibitor
Chemotherapy is a cornerstone in the development of present-day cancer therapy. Moreover, Chemotherapy is one of the most effective and potent strategies to treat malignant tumors. However, Chemotherapy resistance occurs when cancers that have been responding to therapy suddenly begin to grow. Rosabulin is a potent tubulin inhibitor. In...