GGTI-2418 is a Highly Potent, Competitive, and Selective GGTase I inhibitor
Members of the Ras and Rho family of GTPases are signal transducers that regulate many biological processes, including cell cycle progression, cell survival, and cell differentiation. When persistently activated, GTPases promote several oncogenic events, including uncontrolled proliferation, resistance to apoptosis, sustained angiogenesis, invasion, and metastasis. The ability of the...
SJ572403 Inhibits the Disordered Cell Cycle Regulator p27Kip1
The p27Kip1 is a member of the universal cyclin-dependent kinase inhibitor family. In particular, the p27Kip1 is a multi-functional CDK inhibitor with prognostic significance in human cancers. The p27Kip1 controls eukaryotic cell division. The p27 also is a putative tumor suppressor gene, regulator of drug resistance in solid tumors,...