VT-107 is a Pan-TEAD Auto-Palmitoylation Inhibitor
TEA domain (TEAD) transcription factors are sequence-specific DNA binding proteins that regulate transcription. TEAD family transcription factors all contain a DNA-binding domain called a TEA domain. In mammals, TEAD consists of four members (TEAD1-TEAD4), and they share high degree of sequence homology and highly similar structural domain architectures. Besides,...