J-113397 is a Potent and Selective ORL1 Receptor Antagonist
The opioid receptor-like (ORL1) receptor, is also known as the nociceptin opioid peptide receptor (NOP). The ORL1 receptor belongs to the opioid subfamily of G protein-coupled receptors whose natural ligand is the 17 amino acid neuropeptide. J-113397 is an opioid agent which was the first potent and highly selective...
PSB-SB-487 is a Potent GPR55 Antagonist
GPR55 (G protein-coupled receptor 55) is a G protein-coupled receptor that in humans is encoded by the GPR55 gene. GPR55, along with GPR119 and GPR18, are novel cannabinoid receptors. Like the CB receptors, GPR55 belongs to the rhodopsin-like seven transmembranes G protein-coupled receptor (GPCR) superfamily. GPR55 and CB2 receptors...
GSK2606414 is an Orally Available PERK Inhibitor
PERK (Protein kinase R (PKR)-like endoplasmic reticulum kinase) is a type I endoplasmic reticulum transmembrane protein. Generally, PERK contains a stress-sensing domain facing the endoplasmic reticulum lumen and a cytosolic kinase domain. Interestingly, PERK is a major component of the unfolded protein response (UPR), which promotes the adaptation of...