Tag: Parkinson’s Disease

PSB-SB-487 is a Potent  GPR55 Antagonist

GPR55 (G protein-coupled receptor 55) is a G protein-coupled receptor that in humans is encoded by the GPR55 gene. GPR55, along with GPR119 and GPR18, are novel cannabinoid receptors. Like the CB receptors, GPR55 belongs to the rhodopsin-like seven transmembranes G protein-coupled receptor (GPCR) superfamily. GPR55 and CB2 receptors...

GSK2606414 is an Orally Available PERK Inhibitor

PERK (Protein kinase R (PKR)-like endoplasmic reticulum kinase) is a type I endoplasmic reticulum transmembrane protein. Generally, PERK contains a stress-sensing domain facing the endoplasmic reticulum lumen and a cytosolic kinase domain. Interestingly, PERK is a major component of the unfolded protein response (UPR), which promotes the adaptation of...