DTHIB is a Direct and Selective Heat Shock Factor 1 (HSF1) Inhibitor
Heat shock factor 1 (HSF1) is a key regulator of the heat shock response. Especially, HSF1 plays an important role in various cancers. In this study, researchers described the identification of a direct HSF1 inhibitor, Direct Targeted HSF1 Inhibitor (DTHIB). DTHIB physically engages HSF1 and selectively stimulates the degradation...
NEO2734 is an Orally Active Dual p300/CBP and BET Bromodomain Selective Inhibitor
NUT midline carcinoma (NMC) is a rare, aggressive subtype of squamous carcinoma. This kind of cancer is usually driven by BRD4-NUT fusion oncoprotein. BRD4, a BET protein, binds to chromatin through its two bromodomains. At the same time, NUT recruits the p300 HAT to activate oncogenic target genes transcription....