AOH1160, an Orally Active PCNA Inhibitor, Exhibits Efferctive Anti-cancer Activity with Low Toxicity
Proliferating cell nuclear antigen (PCNA) is an auxiliary protein of DNA polymerase delta. PCNA plays an essential role in regulating DNA synthesis and repair and is indispensable to cancer cell growth and survival. In this study, Long Gu, et al identified a potent PCNA inhibitor AOH1160 by targeting a...