Nimotuzumab is a Humanized IgG1 Monoclonal Antibody Targeting EGFR
The epidermal growth factor receptor (EGFR) is a transmembrane protein. The dimerization of EGFR stimulates the activity of intracellular protein tyrosine kinase. Therefore, several tyrosine (y) residues in the C-terminal domain of EGFR undergo autophosphorylation. These include y992, y1045, y1068, y1148, and y1173, as shown in the adjacent chart....
SIS3 is a Potent and Selective Inhibitor of Smad3 Phosphorylation
Smad contains a series of proteins with similar structures, which are the main signal transducer in transforming growth factors β (TGF-b) superfamily. Specifically, they play an important role in the regulation of cell development and growth. One mechanism of Smads promoting TGF-b-induced cell arrest is down-regulation of Myc, a...
BMSpep-57 is a Competitive Peptide Inhibitor of PD-1/PD-L1 Interaction
Programmed cell death 1 (PD-1) is a cell surface receptor. PD-1 is highly expressed on tumor-specific T cells. It is a T cell checkpoint and plays a central role in regulating T cell exhaustion. Programmed cell death ligand 1 (PD-L1) is a trans-membrane protein. PD-L1 is a co-inhibitory factor...
TPP-1 is a Potent Inhibitor of the PD-1/PD-L1 Interaction
PD-L1 is expressed in many types of cancers. And its high expression in tumor cells or presence in TME can be indicative of tumor-infiltrating lymphocytes (TILs). Blockade of PD-1/PD-L1 can strengthen the function of effector T cells. Blockade of PD-1/PD-L1 can strengthen the function of effector T cells. Additionally,...
CB-1158 is a Potent and Orally Active Arginase Inhibitor
Myeloid cells are an abundant leukocyte in many types of tumors and contribute to immune evasion. The major populations of tumor-infiltrating myeloid cells include tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and granulocytes. A feature common to all of these immunosuppressive cells is their expression of the enzyme arginase...