Tag: PDGFR

PD-089828 is an Inhibitor of FGFR-1, PDGFR-β, EGFR and c-Src Tyrosine Kinase

Protein tyrosine kinases comprise a group of enzymes. They catalyze the phosphorylation of certain proteins on specific tyrosine residues. The growth factor receptor tyrosine kinases are a subfamily. The kinases are activated on the high-affinity binding of growth factors to their cognate receptors. Members of this subfamily include PDGFR...

PD-161570 is an Inhibitor of FGF-1R, PDGFR, EGFR and c-Src Tyrosine Kinases

Fibroblast growth factors (FGF) are a family of cell-signaling proteins, which are involved in many processes, especially as the key factor of normal development. In addition, the FGFR family consists of a group of four homologous receptor tyrosine kinases. Besides, FGF1 was a member of a family of FGF...

SU16f is a Selective PDGFRβ Inhibitor for Gastric Cancer Therapy

Mesenchymal stem cells (MSCs) are multipotent progenitor cells that play a critical role in tissue regeneration. MSCs play an important role in matrix remodeling, fibroblast activation, angiogenesis, and immunomodulation. MSCs are an integral part of fibrovascular networks that form in developing tissues and tumors. A multitude of soluble proteins...

JNJ-10198409, an orally active PDGF-RTK inhibitor

As we all know, angiogenesis plays an essential role in the physiology of neonatal development, reproduction, and wound healing. PDGF-BB (Platelet-derived growth factor-BB ) is a mitogenic factor for smooth muscle cells and pericytes. PDGF-BB participates in the later stages of angiogenesis by surrounding endothelial cells to stabilize the...

Vorolanib is an Orally Active Inhibitor of VEGFR and PDGFR 

Vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) are cell-surface tyrosine kinase receptors. They represent targets for anticancer therapy in solid tumors. For accurately validating the therapeutic potential of these target-specific agents, the in vivo quantification of VEGFR/PDGFR activity is critically important. It is not...