VU0155069, a Selective PLD1 Inhibitor, Blocks Tumor Cell Invasion
Phospholipase D (PLD) belongs to the phospholipase superfamily, which widely exists in animals, plants, yeast, bacteria, and viruses. In mammalian cells, there are two PLD isoforms, PLD1 and PLD2. The enzyme involves in various physiological processes, such as membrane trafficking, cytoskeletal reorganization, and cell migration. PLD is also related...