BLU2864 is An Orally Active PRKACA Kinase Inhibitor
Fibrolamellar carcinoma (FLC) is a rare, difficult-to-treat liver cancer primarily affecting pediatric and adolescent patients. An analysis of FLC tumor samples shows that protein kinase A (PKA) alpha catalytic subunit (PRKACA) is a critical molecular event in FLC pathogenesis. In this article, we will introduce an orally active, highly selective, ATP-competitive PRKACA...
Staurosporine is an ATP-competitive Inhibitor of Protein Kinases
Protein kinases are enzymes that catalyze protein phosphorylation. Obviously, Protein kinases include many types of kinases, such as PKC，PKA, c-Fgr and phosphorylase kinase. Thereinto, PKC, PKA and phosphorylase kinase belong to serine or threonine kinases and c-Fgr belongs to Tyr kinases. Interestingly, diacylglycerol (DG) can activate PKC and the...