PP2A - Network of Cancer Research

SMAP-2 (DT-1154) is an Orally Bioavailable PP2A Activator

Louis Gilman June 1, 2021

Protein Phosphatase 2A (PP2A) is a serine/threonine phosphatase. It regulates multiple signaling cascades implicated in cancer progression, including downstream effectors of KRAS. Inhibition of PP2A contributes to oncogenesis in multiple…

Lung Adenocarcinoma Lung Cancer Non-Small Cell Lung Cancer

DT-061 is an Orally Active PP2A Activator

Louis Gilman May 21, 2021

Protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases, minimally containing a well-conserved catalytic subunit. PP2A plays a prominent role in the regulation of specific signal transduction cascades. Additionally,…