Tag: prostate cancer

KGP94 is a Selective Inhibitor of Cathepsin L for Cancer Research

Cathepsin L is a lysosomal cysteine protease. Particularly, it may play a key role in various biological and disease processes through intracellular and extracellular protein degradation. Obviously, cathepsin L is a ubiquitously expressed cysteine protease located in lysosomes under normal conditions. However, cancer cells secrete cathepsin L to help...

Rucaparib (AG014699) is an Orally Active PARP-1/2/3 Inhibitor

Poly (ADP-ribose) polymerase (PARP), a family of proteins, is involved in various cellular processes such as DNA repair and programmed cell death. PARP presents in the cell nucleus. It consists of a DNA-binding domain, a caspase-cleaved domain, an auto-modification domain, and a catalytic domain. In particular, the protein can...