ML-099 is a pan Ras-Related GTPases Activator
To date, we identified 167 small GTPases in humans which are key signal transducing enzymes. Small GTPases comprise five main families whose eponymous members are Ras, Rho, Rab, ADP-ribosylation factor…
CID-1067700 is a Ras GTPases pan-Inhibitor with High Efficacy Towards Rab7
Alteration of small GTPase functions is a hallmark of genetic and sporadic human diseases, making GTPase family members attractive though understudied targets. Specifically, the Ras superfamily of GTPases includes Arf,…