CID44216842 is a Potent Cdc42-Selective Guanine Nucleotide Binding Lead Inhibitor
Cdc42, a small GTPase of the Rho family, plays important roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. Overactive Cdc42 has been implicated in the pathology of cancers, immune diseases, and neuronal disorders. Therefore, Cdc42 inhibitors will be useful in probing molecular pathways and could...