RKI-1313 is a Potent ROCK1/2 inhibitor
ROCK is a kinase belonging to the AGC (PKA/PKG/PKC) family of serine threonine-specific protein kinases. Specifically, ROCK is one of the best characterization effectors of RhoA, a small GTPase. It mainly regulates the shape and movement of cells by acting on the cytoskeleton. Besides, ROCK is the main downstream...
HSD1590 is Potent ROCK Inhibitor with Low Cell Toxicity
Rho-associated protein kinases (ROCKs) are serine-threonine kinases contain isoforms ROCK1 and ROCK2. ROCK1 and ROCK2 exhibit 60% sequence homology and 90% kinase domain homology. The 2 isoforms exist in many organs/tissues but have different expression levels. ROCK1 mainly expresses in thymus, tongue, spleen, and cervix, et al. ROCK2 exists...