Tag: ROS

JX06 is a Potent, Selective and Covalent Inhibitor of PDK

Pyruvate dehydrogenase kinase (PDK) is a kinase that can be inactivated by the use of ATP phosphorylation of pyruvate dehydrogenase. Specifically, PDK is relevant to the regulation of the pyruvate dehydrogenase complex with pyruvate dehydrogenase as the first component. Besides, PDK acts as a molecular switch to reduce mitochondrial...

RA375, a RPN13 Inhibitor, Activates UPR Signaling, ROS Production and Apoptosis

Rpn13 is a known component of the proteasome. Especially, Rpn13 binds ubiquitin-like domains of the UBL/UBA family of ubiquitin receptors. Rpn13, as an ubiquitin receptor, offers a docking position for ubiquitinated substrate. RA375 is a RPN13 inhibitor. Treatment with RA375 causes a rapid and profound accumulation of high molecular weight polyubiquitinated proteins. RA375...