Scientists find a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor epacadostat through a series of SAR studies. It primarily focused on improving the PK by reducing the rate of…
KRAS plays a critical role in regulating cell growth and division. KRAS mutations are common in many types of solid tumors, including lung, colon, and pancreatic cancers, and are associated…
In this article, we will introduce a potent humanized IgG4k monoclonal antibody against programmed death-1 (PD-1) Geptanolimab. As a result, Geptanolimab inhibits the binding of PD-L1/L2 to PD-1 through a…
On December 1, 2022, FDA approved Rezlidhea (Olutasidenib) to treat adults with relapsed or refractory acute myeloid leukemia (AML) with a susceptible (IDH1) mutation. Olutasidenib (FT2102) is a highly potent,…
The Vanilloid group (TRPV) contains six members, from TRPV1 to TRPV6. TRPV5 and TRPV6 exhibit lower sequence identity to V1-V4, and different properties. Additionally, TRPV5 or TRPV6 is selective for…
PARP is a family of proteins involved in many cellular processes, such as DNA repair, genomic stability, and programmed cell death. At least 18 members of the PARP family are…