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Reliable, unbiased and up to date information in cancer research

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Cancer

Chrysotoxine is a Dual Src/Akt Inhibitor for Cancer Research

Louis Gilman October 24, 2023

Cancer stem cells (CSCs) hold the center control for heterogeneity of cancer cells in tumors as they proliferate and differentiate to other cells with a lower hierarchy of stemness line…

Breast Cancer Lung Cancer Non-Small Cell Lung Cancer

Rigosertib is a Multi-Kinase Inhibitor and a Selective Anti-Cancer Agent

Louis Gilman March 8, 2022

Polo-like Kinases (PLKs) are a group of highly conserved serine/threonine protein kinases. PLKs play a key role in processes such as cell division and checkpoint regulation of mitosis. Mammalian cells…

Bladder Cancer Prostate Cancer

Saracatinib (AZD0530) is a potent Src Family Inhibitor

Louis Gilman October 21, 2021

Src is a prototypical non-receptor tyrosine kinase. It also includes c-Yes and Fyn. Src transduces signals that control processes involved in cell proliferation, adhesion, and motility. Clinical evidence supports a…

Breast Cancer Lung Cancer Non-Small Cell Lung Cancer Triple-Negative Breast Cancer

DGY-06-116 is an Irreversible Covalent and Selective Src Inhibitor

Louis Gilman June 17, 2021

Src kinase family is a family of non-receptor tyrosine kinases. DGY-06-116 is a selective Src inhibitor. DGY-06-116 is an SRC-directed covalent kinase inhibitor that displays efficient covalent target labeling and…

Chronic Myeloid Leukemia Leukemia

Dasatinib is an Orally Active Dual Bcr-Abl and Src Family Tyrosine Kinase Inhibitor

Louis Gilman April 17, 2021

Src is an important member of the non-receptor protein tyrosine kinase. Furthermore, Src plays a key role in the regulation of many cells through the extracellular ligand binding to the…

Cancer

A 419259 is a Potent Src Inhibitor

Louis Gilman October 8, 2020

Chronic myelogenous leukemia (CML) is a human malignancy and affects hematopoietic progenitor cells. The CML is driven by Bcr-Abl. Additionally, Bcr-Abl is a 210 kDa chimeric tyrosine kinase that transforms…

Cancer

SM1-71 is a Multi-Targeted Kinase Inhibitor with Anti-Cancer Activity

Louis Gilman September 1, 2020

In this article, we will introduce a potent TAK1 inhibitor, with a Ki of 160 nM. SM1-71 inhibits MEK1 activities with an IC50 of 142 nM. It also exhibits only weak activity against…

Cancer

CGP77675 is an Orally Active Inhibitor of Src Family Kinases

Louis Gilman May 30, 2020

Src kinase family is a nonreceptor tyrosine kinase family. It includs 9 members: SRC, yes, Fyn and FGR, Lck, HCK, BLK, and Lyn. Specifically, Src family kinases interact with many…

Solid Tumors

AZD0424 is an Orally Active and Dual Selective Src/Abl Kinase Inhibitor

Louis Gilman September 25, 2019

A study from Victoria K Woodcock suggested that AZD0424 is an inhibitor of the proto-oncogenic non-receptor tyrosine kinases Src and ABL1. The kinase plays an indefensible role in cancer. Src…

Acute Myeloid Leukemia

TL02-59 is a Selective and Orally Active Myeloid Src-family Kinase Fgr Inhibitor

Louis Gilman September 17, 2019

Acute myelogenous leukemia (AML) is a devastating hematologic cancer with limited treatments. Scientists have demonstrated that diverse genetic changes are associated with AML. Especially, the upregulation of tyrosine kinase signaling…

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Recent Posts

  • Erlotinib is an EGFR TKI for NSCLC and Pancreatic Cancer Research
  • Parsaclisib is an Orally Active PI3Kδ Inhibitor for B-cell Malignancies Research
  • Nilotinib is an Orally Active Bcr-Abl Tyrosine Kinase Inhibitor for CML Research
  • Temsirolimus is an mTOR Inhibitor for Kinds of Cancers Research
  • Toripalimab is an Anti-tumor PD-1 Antibody for Nasopharyngeal Carcinoma Research

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You Missed

NSCLC Pancreatic cancer

Erlotinib is an EGFR TKI for NSCLC and Pancreatic Cancer Research

B-cell malignancies

Parsaclisib is an Orally Active PI3Kδ Inhibitor for B-cell Malignancies Research

Leukemia

Nilotinib is an Orally Active Bcr-Abl Tyrosine Kinase Inhibitor for CML Research

Acute Lymphoblastic Leukemia Cancer Prostate Cancer

Temsirolimus is an mTOR Inhibitor for Kinds of Cancers Research

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