Dazostinag is a STING Agonist and Can be used for Antibody-Drug Conjugates (ADCs) Synthesis
STING, stimulator of interferon gene, is an important protein in innate immunity. It can induce the production of type I interferon. STING performs an antiviral activity and innate immune response to inhibit intracellular pathogens. ADCs, antibody-drug conjugates, are popular targeted therapies tools for cancer. An ADC consists of a...
MSA-2 is an Orally Available STING Agonist with Anti-tumor Activity
Stimulator of interferons genes (STING) is an adaptor protein. It plays a critical role in the secretion of type I interferons and pro-inflammatory cytokines in response to cytosolic nucleic acid. STING is also an endoplasmic reticulum-associated homodimeric protein. It is the receptor for cGAMP. The cGAMP is a second...
IACS-8803 is a Cyclic Dinucleotide STING Agonist
The stimulator of interferon genes (STING) is an innate pattern recognition receptor natively exists in the endoplasmic reticulum (ER). STING has a great effect on host defense through supervising pathogenic or damage-associated nucleic acids. Since the generation of optimal adaptive anti-tumor immune responses requires the STING signal, activation of...