FL118, a Camptothecin Analogue, is a Survivin Inhibitor with Anti-Cancer Activity
Survivin is the smallest member of the inhibitor of apoptosis (IAP) protein family. Specifically, survivin is a 142 amino acid, 16.5 kDa protein. Survivin participates in the inhibition of apoptosis and the regulation of the cell cycle. Besides, survivin can inhibit caspase and block cell death. Moreover, survivin was...
NSC 80467 is a DNA Damaging Agent and a Selective Survivin Suppressant
Each of the ~1013 cells in the human body receives tens of thousands of DNA lesions per day. These lesions can block genome replication and transcription. If they are not repaired or are repaired incorrectly, they lead to mutations or wider-scale genome aberrations that threaten cell or organism viability....
LQZ-7I is an Orally Active Survivin-Targeting Inhibitor
Survivin is a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases and blocks cell death. Caspases highly expressed in most cancers and are associate with a poor clinical outcome. The differential expression of survivin in cancer cells compared to normal tissues and its role as...