VT-107 is a Pan-TEAD Auto-Palmitoylation Inhibitor
TEA domain (TEAD) transcription factors are sequence-specific DNA binding proteins that regulate transcription. TEAD family transcription factors all contain a DNA-binding domain called a TEA domain. In mammals, TEAD consists of four members (TEAD1-TEAD4), and they share high degree of sequence homology and highly similar structural domain architectures. Besides,...
TED-347 is an Irreversible and Covalent YAP-TEAD Protein-Protein Interaction Inhibitor
Yap1, also known as Yap, is a protein that acts as a transcription regulator by activating the transcription of genes involved in cell proliferation and inhibiting apoptosis. Specifically, Yap1 is inhibited in the hippopotamus signaling pathway, which can control organ size and inhibit tumors. Besides, hippopotamus signaling regulates Yap1...