BMS453 is a RARβ Agonist and a RARα/RARγ Antagonist
Retinoids inhibit the growth of many human tumor cells. Retinoids are ligands of retinoic acid receptors alpha, beta, gamma (RARs, α, β and γ). Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth and survival. BMS453 is...
6RK73 is a Covalent Irreversible and Specific UCHL1 Inhibitor
Approximately 90% of breast cancer-related deaths are due to metastasis. During the metastasis process, epithelial-mesenchymal transition (EMT) plays an important role. The secreted cytokine transforming growth factor-β (TGFβ) can induce it. Breast cancer has multiple subtypes with distinct metastatic potential based on genetic and clinical features. The most aggressive...