NU9056 is a Selective Tip60 (KAT5) Histone Acetyltransferase Inhibitor
Histone acetylation and deacetylation are key events in the regulation of chromatin structure. Additionally, Histone acetyltransferases (HATs) can catalyze acetyl groups to the ε-amino terminus of lysine residues within histones. Acetylation results in an open chromatin structure by removing positive charges from histones. As a result, it induces protein...
TH1834 is a Specific Tip60 Histone Acetyltransferase (HAT) Inhibitor
Many aspects of genome regulation and metabolism require histone acetylation. Accordingly, dysfunctional histone acetylation has been implicated in numerous diseases, including cancer. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate acetylation of histones and non-histone. HATs catalyze the acetylation of core histones through the addition of an acetyl group...