Tag: TNF-α

APG-1387, a Bivalent SMAC Mimetic, Induces Proteasomal Degradation of IAPs

Apoptosis protein inhibitors (IAP) are a class of functional and structural proteins, which are endogenous inhibitors of apoptosis. Specifically, inappropriate mutation or regulation will usually lead to cancer or other effects on cells. They include the Bcl-2 family, viral inhibitor crmA, and IAP’s. Besides, the most characteristic of IAAP...

MSA-2 is an Orally Available STING Agonist with Anti-tumor Activity

Stimulator of interferons genes (STING) is an adaptor protein. It plays a critical role in the secretion of type I interferons and pro-inflammatory cytokines in response to cytosolic nucleic acid. STING is also an endoplasmic reticulum-associated homodimeric protein. It is the receptor for cGAMP. The cGAMP is a second...