IMD-0354 is a Selective IKKβ Inhibitor
IKKβ is an enzyme that is part of an intracellular signaling pathway activated by cytokines involved in triggering an immune response. Particularly, Phosphorylated IκB degrades and releases NF-κB through the ubiquitination pathway. Importantly, it enters the nucleus and participates in a variety of genes in inflammation and other immune...
Lenalidomide, a Ligand of CRBN, is an Orally Active Immunomodulator
Immunomodulatory imide drugs (IMiDs) are a class of immunomodulatory drugs containing an imide group. The discovery of anti-angiogenic and anti-inflammatory properties promoted the development of Thalidomide analogs. These compounds bind Cereblon (CRBN), the substrate adaptor for the CRBN-CRL4 E3 ubiquitin ligase, and modulate the substrate specificity of the enzyme....
APG-1387, a Bivalent SMAC Mimetic, Induces Proteasomal Degradation of IAPs
Apoptosis protein inhibitors (IAP) are a class of functional and structural proteins, which are endogenous inhibitors of apoptosis. Specifically, inappropriate mutation or regulation will usually lead to cancer or other effects on cells. They include the Bcl-2 family, viral inhibitor crmA, and IAP’s. Besides, the most characteristic of IAAP...
MSA-2 is an Orally Available STING Agonist with Anti-tumor Activity
Stimulator of interferons genes (STING) is an adaptor protein. It plays a critical role in the secretion of type I interferons and pro-inflammatory cytokines in response to cytosolic nucleic acid. STING is also an endoplasmic reticulum-associated homodimeric protein. It is the receptor for cGAMP. The cGAMP is a second...