OTS514 is a Highly Potent TOPK Inhibitor with Anti-Myeloma Activity
Multiple myeloma represents a heterogeneous disease with various oncogenic mutations, chromosomal translocations, and copy number variations. The mitotic kinase T-LAK cell‐originated protein kinase/PDZ‐binding kinase ( TOPK/PBK) associates with the proliferation of tumor cells, maintenance of cancer stem cells, and poor patient prognosis in many cancers. In addition, TOPK plays...
OTS964 is an Orally Active TOPK and CDK11 Inhibitor
TOPK (T–lymphokine-activated killer cell–originated protein kinase, also known as PBK or PDZ-binding kinase) is a Ser/Thr protein kinase. Many types of human cancer, including breast and lung cancers, highly expresses it. Thus, TOPK might be a promising molecular target for drug development. Moreover, TOPK is in the “consensus stemness...