Skip to content

Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

  • Home
  • About
    • Home
    • Topoisomerase
Cancer

ARN24139 is a TopoII Inhibitor with Promising Antiproliferative Activity

Louis Gilman February 23, 2023

Topoisomerase II is a ubiquitous enzyme in all branches of life that alters DNA supercoils and breaks double-stranded DNA fragments during processes such as replication and transcription. Eukaryotic Topoisomerase II…

Acute Leukemia Acute Lymphoblastic Leukemia Leukemia

Daunorubicin is a Topoisomerase II Inhibitor with potent Antineoplastic Activities

Louis Gilman November 2, 2021

Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. Topoisomerases are isomerase enzymes…

Colon Cancer

SN-38 (NK012) is an Active Metabolite of the Topoisomerase I Inhibitor Irinotecan

Louis Gilman September 9, 2021

DNA topoisomerase I (Top1) is a DNA unwinding protein and the specific target of the camptothecin class of chemotherapeutic drugs. Top1 binds supercoiled DNA, nicks a DNA strand allowing its…

Fibrosarcoma

CRT0044876 is a Potent and Selective APE1 Inhibitor

Louis Gilman September 9, 2020

The base excision repair (BER) pathway is essential for the removal of DNA bases damaged by alkylation or oxidation. This pathway also handles a variety of other lesions including deaminated…

Colon Cancer Lung Cancer Non-Small Cell Lung Cancer

TP3011 is a Potent Topoisomerase-1 Inhibitor with Anti-tumor Effect

Louis Gilman April 18, 2020

Topoisomerases are proteins that cut the DNA backbone. Especially, topoisomerases let the cut ends twist past each other to a more relaxed configuration. Moreover, topoisomerases reseal the phosphodiester bonds in…

Breast Cancer Colon Cancer Lung Cancer Ovary Cancer

NU1025 is a Potent PARP Inhibitor with Anti-Cancer and Neuroprotective Activity

Louis Gilman April 7, 2020

Excessive glutamate release, Ca++ overload, free radical generation, poly (ADP-ribose) polymerase (PARP) overactivation are the main events of neuronal cell death in ischemic stroke. Besides, stroke is a third leading…

Lymphoma

SB-218078 is an ATP Competitive and Reversible Chk1 Inhibitor

Louis Gilman February 18, 2020

Research from Jeffrey R. Jackson, et al. discovered and identified an indolocarbazole inhibitor of human checkpoint Kinase (Chk1) SB-218078. SB-218078 is an ATP Competitive and Reversible Chk1 Inhibitor The regulation…

Solid Tumors

DRF-1042 is an Orally Active DNA topoisomerase I Inhibitor

Louis Gilman December 24, 2019

Inhibitors of the enzyme topoisomerase I are cytotoxic for tumor cells because of their ability to cause DNA damage. Specifically, DNA Topoisomerase I (Top1) is one main cellular factor controlling…

Recent Posts

  • Irinotecan is a Topoisomerase I Inhibitor for Colorectal Cancer Research
  • Copanlisib is a Pan-class I PI3K Inhibitor for Lymphoma Resaerch
  • Erlotinib is an EGFR TKI for NSCLC and Pancreatic Cancer Research
  • Parsaclisib is an Orally Active PI3Kδ Inhibitor for B-cell Malignancies Research
  • Nilotinib is an Orally Active Bcr-Abl Tyrosine Kinase Inhibitor for CML Research

Archives

  • December 2023
  • November 2023
  • October 2023
  • September 2023
  • August 2023
  • July 2023
  • June 2023
  • May 2023
  • April 2023
  • March 2023
  • February 2023
  • January 2023
  • December 2022
  • November 2022
  • October 2022
  • September 2022
  • August 2022
  • July 2022
  • June 2022
  • May 2022
  • April 2022
  • March 2022
  • February 2022
  • January 2022
  • December 2021
  • November 2021
  • October 2021
  • September 2021
  • August 2021
  • July 2021
  • June 2021
  • May 2021
  • April 2021
  • March 2021
  • February 2021
  • January 2021
  • December 2020
  • November 2020
  • October 2020
  • September 2020
  • August 2020
  • July 2020
  • June 2020
  • May 2020
  • April 2020
  • March 2020
  • February 2020
  • January 2020
  • December 2019
  • November 2019
  • October 2019
  • September 2019
  • August 2019
  • July 2019
  • June 2019
  • May 2019
  • April 2019
  • March 2019

Categories

  • Abdominal Aortic Aneurysm
  • Acute Leukemia
  • Acute Lymphoblastic Leukemia
  • Acute Myeloid Leukemia
  • Adenoid Cystic Carcinoma
  • Adenomyosis
  • Adrenocortical carcinoma
  • Adult T-cell leukemia/lymphoma
  • Anti-angiogenic
  • anti-inflammatory
  • antioxidant
  • autoimmune disease
  • B-cell malignancies
  • Bladder Cancer
  • Bone Cancer
  • Brain Cancer
  • Breast Cancer
  • Cancer
  • Cancer Metastases
  • Castration Resistant Prostate Cancer
  • ccRCC
  • Cervical Cancer
  • Cervix Cancer
  • Chemotherapy
  • Chemotherapy Side Effects
  • Cholangiocarcinoma
  • Chronic Lymphocytic Leukemia
  • Chronic Myeloid Leukemia
  • Colon Adenocarcinoma
  • Colon Cancer
  • Colorectal Cancer
  • Colorectal Cancer
  • Endometrial Adenocarcinoma
  • Endometrial Cancer
  • ER+ Breast Cancer
  • Esophageal Squamous Cell Carcinoma
  • Esophagus Cancer
  • Ewing's Sarcoma
  • Fibrosarcoma
  • Follicular Lymphoma
  • Gastric Adenocarcinoma
  • Gastric Cancer
  • Gastrointestinal Stromal Tumor
  • Glioblastoma
  • Glioblastoma Multiforme
  • Gliocytoma
  • Glioma
  • Head & Neck Cancer
  • Head and Neck Cancer
  • Hematologic Neoplasms
  • Hematological Malignancies
  • Hepatocellular carcinoma
  • HER2+ Breast Cancer
  • Hodgkin Lymphoma
  • HPV
  • HSV-1
  • Idiopathic Pulmonary Fibrosis
  • Kaposi's Sarcoma
  • Kidney Cancer
  • Large B Cell Lymphoma
  • Large B-cell Lymphoma
  • Large Cell Lung Cancer
  • Leukemia
  • Liver Cancer
  • Lung Adenocarcinoma
  • Lung Cancer
  • Lymphoma
  • Malaria
  • Mantle Cell Lymphoma
  • Medullary Thyroid Carcinoma
  • Medulloblastoma
  • Medulloblastomas
  • Megakaryoblastic Leukemia
  • Melanoma
  • Mesothelioma
  • Metabolism
  • Metabolism-related diseases
  • Metastatic Castration-resistant Prostate Cancer
  • Multiple Myeloma
  • Myelodysplastic Syndrome
  • Myelodysplastic Syndrome
  • Myeloma
  • Nasopharyngeal Carcinoma
  • Neoplasms
  • Neuroblastoma
  • Neuroendocrine Tumors
  • Neuropathy
  • Non-Hodgkin Lymphoma
  • Non-Small Cell Lung Cancer
  • NSCLC
  • NUT midline carcinoma
  • Obesity
  • Oesophageal Cancer
  • Oral Carcinoma
  • Osteosarcoma
  • Ovary Cancer
  • Pancreas Cancer
  • Pancreatic cancer
  • Pancreatic cancer
  • Pancreatic Ductal Adenocarcinoma
  • Ph+ ALL
  • Philadelphia-positive Leukemias
  • Plasmacytoma
  • Prostate Cancer
  • PROTAC
  • Renal Carcinoma
  • Sarcoma
  • Skin Cancer
  • Small Cell Lung Cancer
  • Soft Tissue Tumor
  • Solid Tumors
  • Squamous Carcinoma
  • Stomach Cancer
  • T Acute Lymphoblastic Leukemia
  • T-cell Lymphoma
  • Thyroid Cancer
  • Triple-Negative Breast Cancer
  • uncategorized
  • Uterine Serous Carcinoma

You Missed

Cancer

Irinotecan is a Topoisomerase I Inhibitor for Colorectal Cancer Research

Cancer Follicular Lymphoma Lymphoma

Copanlisib is a Pan-class I PI3K Inhibitor for Lymphoma Resaerch

NSCLC Pancreatic cancer

Erlotinib is an EGFR TKI for NSCLC and Pancreatic Cancer Research

B-cell malignancies

Parsaclisib is an Orally Active PI3Kδ Inhibitor for B-cell Malignancies Research

Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

Copyright © All rights reserved | Blogus by Themeansar.