COH000 is an Allosteric, Covalent and Irreversible Inhibitor of SUMO-Activating Enzyme
Aberrations in post-translational modifications by ubiquitin or ubiquitin-like proteins (Ubl), such as the small ubiquitin-like modifiers (SUMO) relate to the pathogenesis of lifethreatening diseases, such as cancer, neurodegenerative disorders, and…