Aberrations in post-translational modifications by ubiquitin or ubiquitin-like proteins (Ubl), such as the small ubiquitin-like modifiers (SUMO) relate to the pathogenesis of lifethreatening diseases, such as cancer, neurodegenerative disorders, and viral infection. For instance, emerging studies have identified the dyregulation of SUMOylation in various cancers. Additionally, the SUMO-activating enzyme...