NV03 is a Selective Antagonist for UHRF1-TTD Interaction with H3K9me3
Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is a potent oncogenic protein. Its overexpression in various solid and blood tumors. Moreover, UHRF1 has an association with reduced expression of tumor suppressor genes, including BRCA1 and PPARγ. UHRF1 contains five functional domains, and each domain could independently carry...