SBI-0206965, a ULK1 Inhibitor, Triggers Apoptosis by Preventing Autophagy and PPP Flux
Autophagy is a central cellular mechanism for the elimination of damaged proteins, protein complexes, and organelles. ATG1 gene is notable for being the only core autophagy gene to encode a serine/threonine kinase. Atg1 forms a complex with multiple regulatory subunits, including Atg13 and Atg17. In mammals, there are two Atg1...
MRT67307 Blocks mTOR-Dependent Autophagy by Inhibiting ULK1 Kinase
Yesterday, I introduced a dual IKKε/TBK1 inhibitor MRT67307. Studies have showed that MRT67307 plays a significant role in innate immunology. Not only this, a study from Katy J. Petherick drew a conclusion that MRT67307 blocked mTOR-dependent autophagy by inhibiting ULK1 kinase. ULK1, is believed to be specific for autophagy....