LYN-1604 is a Potent ULK1 Activator
UNC-51 like kinase 1 (ULK1) is the mammalian homolog of ATG1. ULK1 is an autophagic initiator that may decide the subsequent cell fate. In the autophagic process, ULK1 is a component…
SBI-0206965, a ULK1 Inhibitor, Triggers Apoptosis by Preventing Autophagy and PPP Flux
Autophagy is a central cellular mechanism for the elimination of damaged proteins, protein complexes, and organelles. ATG1 gene is notable for being the only core autophagy gene to encode a serine/threonine…
MRT67307 Blocks mTOR-Dependent Autophagy by Inhibiting ULK1 Kinase
Yesterday, I introduced a dual IKKε/TBK1 inhibitor MRT67307. Studies have showed that MRT67307 plays a significant role in innate immunology. Not only this, a study from Katy J. Petherick drew…