USP7 - Network of Cancer Research

U7D-1 is a Selective USP7 PROTAC Degrader For Leukemia Research

Louis Gilman December 6, 2022

Ubiquitin-specific proteinase 7 (USP7) is a kind of de ubiquitination enzyme (DUB), which can remove ubiquitin and protect substrate protein from degradation. Besides, the full activity of USP7 requires the…

Colorectal Cancer

PR-619 is a Broad-Range DUB Inhibitor

Louis Gilman February 20, 2021

Ubiquitination is a post-translational modification where the polypeptide ubiquitin is attached to lysine residues of substrate proteins. This process is reversible, and ubiquitin removal is orchestrated by a large family…

Breast Cancer

U7D-1 is a Selective USP7 PROTAC Degrader For Leukemia Research

PR-619 is a Broad-Range DUB Inhibitor

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