Tag: VEGF

Tasisulam, an Antitumor Agent, Inhibits Mitotic Progression and Induces Apoptosis

Tasisulam is an acyl sulfonamide with a unique antitumor dual mechanism of action. It involves antiangiogenesis and mitotic inhibition. Tasisulam has a broad range of activity in 60 tumor cell lines. It includes leukemia, melanoma, non-small-cell lung cancer, colon, ovarian, renal, and breast cancers. In this study, Tasisulam is...

PTC299 is an Oral Active and Dual Inhibitor of DHODH and VEGF

De novo pyrimidine nucleotide biosynthesis is activated in proliferating cancer cells in response to an increased demand for synthesis of DNA, RNA and phospholipids. The synthesis activates via oncogenic pathways, such as Myc, PI3K, PTEN and mTOR. Dihydroorotate dehydrogenase (DHODH) locates on the surface of the inner mitochondrial membrane,...