A 83-01 is a Potent Inhibitor of TGF-β Type I Receptor ALK5 Kinase
TGF-β, activin, nodal, and bone morphogenetic proteins (BMPs) belong to the TGF-β superfamily. It regulates a wide range of cellular responses, including cell proliferation, differentiation, adhesion, migration, and apoptosis. TGF-β and related proteins transduce signals through two distinct serine/threonine kinase receptors, including type I and type II. The function...
NCGC00378430 is a Potent SIX1/EYA2 Interaction Inhibitor
The Sine oculis homeobox homolog 1 (SIX1)/eyes absent (EYA) transcription complex plays a key role in the development of multiple organs. Specifically, members of the SIX gene family encode proteins characterized by different DNA binding homologous domains and upstream six domains. This may involve determining DNA binding specificity and...
LDN193189 is a Selective BMP Type I Receptor Inhibitor
Fibrodysplasia ossificans progressiva (FOP) is a congenital disorder of progressive. It is widespread postnatal ossification of soft tissues and is without known effective treatments. A recent study identified heterozygous mutations in ACVR1, the gene encoding the BMP type I receptor ALK2, in all affected members from seven families. BMP...