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Reliable, unbiased and up to date information in cancer research

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Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Louis Gilman September 29, 2023

STING, refers to the stimulator of interferon genes, is an endoplasmic reticulum (ER) membrane-bound adapter protein. It binds to cGAMP and send a dramatic conformational change. Thereby STING triggers itself translocation from…

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Louis Gilman September 28, 2023

c-Met is a receptor tyrosine kinase involved in embryogenesis, wound healing, and tissue regeneration. Abnormal activation of the MET signaling pathway promotes the growth, survival, migration and invasion of tumor…

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

Louis Gilman September 27, 2023

Nowadays, Checkpoint inhibitors for cancer therapy have shown great benefits. Besides, amino acid metabolism is important in the regulation of the immune response. As the critical enzymes in metabolic pathways,…

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

Louis Gilman September 26, 2023

Programmed death-1 (PD-1) is a cell surface receptor that functions as a T cell checkpoint and plays a central role in regulating T cell exhaustion. Meanwhile, programmed death-ligand 1 (PD-L1)…

Acute Lymphoblastic Leukemia Multiple Myeloma NSCLC

Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

Louis Gilman September 22, 2023

HDAC inhibitors are a class of anticancer agents. HDAC inhibitors have shown antitumor effects in a variety of cancer cell lines, such as NSCLC, prostate, colon, ovarian, breast, bladder, pancreas,…

Glioblastoma Multiforme Gliocytoma

GW2974 is an EGFR/HER2 Inhibitor for Glioblastoma Multiforme Research

Louis Gilman September 21, 2023

The human EGF receptor (HER) 2 receptor tyrosine kinase is a survival factor for human cardiomyocytes. It plays an essential role in cardiac development during embryogenesis. Here, we will introduce…

Acute Myeloid Leukemia

Wu-5 is a USP10 Inhibitor for Acute Myeloid Leukemia Research

Louis Gilman September 19, 2023

Fms-related tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase expresses on hematopoietic cells. However, FLT3 plays a critical role in both normal and malignant hematopoiesis. According to existing research…

Cancer Neuropathy

Lactacystin is a Proteasome Inhibitor for Cancer and Kinds of Diseases Research

Louis Gilman September 18, 2023

Proteasomes are very large protein complexes inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm. The main function of…

Acute Leukemia

MSN8C is a DNA top II inhibitor for Leukemia Research

Louis Gilman September 15, 2023

Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA. The double stranded nature of DNA creates a special set of problems for processes that require strand unwinding such…

Gastric Cancer

LC-MB12 is a FGFR2 PROTAC Degrader for Gastric Cancer Research

Louis Gilman September 14, 2023

Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10.…

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Recent Posts

  • BI 7446 is a STING Agonist for Immuno-oncology Research
  • JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research
  • OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research
  • INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research
  • Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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