NU6102 is a Potent CDK1 and CDK2 Inhibitor

CDKs remain attractive targets for anti-proliferative cancer chemotherapy. they play a central role in cell division and growth.  Amongst the cell cycle CDKs, CDK2 has attracted the most attention and its exploitation as a drug target based on structure-based drug design. In this article, we will introduce a potent...

CMLD-2 is Inhibits HuR and Induces Apoptosis

Hu antigen R (HuR) is an RNA binding protein. Specifically, Its overexpression in human cancer is associated with aggressive disease, drug resistance, and poor prognosis. HuR is highly abundant in many types of cancer and promotes tumorigenesis through cancer-related mRNA interactions. Besides, HuR has related to the regulation of...

Senaparib is a Selective and Orally Active PARP1/2 Inhibitor

Poly(ADP-ribose) polymerase (PARP) is an important protein in DNA repair pathways especially the base excision repair. . PARP proteins compose of two ribose moieties and two phosphates per unit polymer. PARP inhibitors represent a successful example of precision medicine as the first drugs targeting DNA damage response to have...

Afatinib is an Irreversible and Orally Active EGFR Family Inhibitor

Lung cancer continues to be the leading cause of cancer-related mortality. Members of the ERBB receptor tyrosine kinase family include EGFR, HER2, HER3, and HER4. They present an attractive option for targeted therapy in patients with NSCLC, due to observed patterns of oncogenic mutation of EGFR and HER2. In addition, esophageal...

NSC-105808 is a Specific DNA2 Nuclease Inhibitor with Antitumor Activity

DNA2 nuclease possesses 5′ flap endonuclease and 3′-5′ helicase activities. It has an important role in DNA damage repair, homologous recombination, and DNA replication. The nuclease activity of DNA2 has several well-documented cellular functions. However, the biological role of its helicase activity remains enigmatic. DNA2 mediates the resection of...

ML786 is an Orally Bioavailable Raf Inhibitor

The mitogen-activated protein kinase (MAPK) signal pathway plays an important role in cells. It also has a response to many different external stimuli and regulates cellular growth, proliferation. The Raf isoform B-Raf is one component of this pathway. Besides, it has a high rate of activating mutation in melanoma...

R59949 is a pan Diacylglycerol Kinase (DGK) Inhibitor

Diacylglycerol kinase (DGK) is a second messenger in its own right and can modulate the activity of PKC and several ion channels.  Chemokines are low MW extracellular signaling peptides secreted by tissue either constitutively during homeostasis or de novo during an inflammatory response. They are a diverse family of...