STING, refers to the stimulator of interferon genes, is an endoplasmic reticulum (ER) membrane-bound adapter protein. It binds to cGAMP and send a dramatic conformational change. Thereby STING triggers itself translocation from…
c-Met is a receptor tyrosine kinase involved in embryogenesis, wound healing, and tissue regeneration. Abnormal activation of the MET signaling pathway promotes the growth, survival, migration and invasion of tumor…
Nowadays, Checkpoint inhibitors for cancer therapy have shown great benefits. Besides, amino acid metabolism is important in the regulation of the immune response. As the critical enzymes in metabolic pathways,…
Programmed death-1 (PD-1) is a cell surface receptor that functions as a T cell checkpoint and plays a central role in regulating T cell exhaustion. Meanwhile, programmed death-ligand 1 (PD-L1)…
HDAC inhibitors are a class of anticancer agents. HDAC inhibitors have shown antitumor effects in a variety of cancer cell lines, such as NSCLC, prostate, colon, ovarian, breast, bladder, pancreas,…
The human EGF receptor (HER) 2 receptor tyrosine kinase is a survival factor for human cardiomyocytes. It plays an essential role in cardiac development during embryogenesis. Here, we will introduce…
Fms-related tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase expresses on hematopoietic cells. However, FLT3 plays a critical role in both normal and malignant hematopoiesis. According to existing research…
Proteasomes are very large protein complexes inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm. The main function of…
Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA. The double stranded nature of DNA creates a special set of problems for processes that require strand unwinding such…
Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10.…