CWP232228 is a Highly Potent and Selective Wnt/β-catenin Inhibitor
Conventional chemotherapy and radiation induce more and more breast cancer stem cells (BCSC) resistance. In recent years, increasing studies have suggested that the dysregulation of Wnt/β-catenin signaling occurs in breast cancer. A study from Gyu-Beom Jang, the researchers showed that the level of Wnt/β-catenin signaling in BCSC is relatively...
DK419 Is a Potent Inhibitor of Wnt/β-Catenin Signaling for Colorectal Cancer Treatment
Colorectal Cancer (bowel cancer; colon cancer) is one of the most serious cancer diseases, with the development from colon or rectum. It is mainly due to old age and environmental factors. Although we have discovered batches of anti-cancer agents, they are still lacking. Wnt/β-Catenin signaling is a canonical Wnt...
A Potent and Specific Tankyrase Inhibitor RK-287107, Blocks Colorectal Cancer Cell Growth
Wnt/β-catenin signaling is activated in over 90% of human colorectal cancer. In particular, loss-of-function mutations of the tumor suppressor adenomatous polyposis coli (APC), a key negative regulator of Wnt/β-catenin signaling, occur in 90% of patients. The secreted Frizzled-related proteins (sFRPs) and Wnt inhibitory protein (WIF) regulate Wnt/b-catenin signaling. Both...