Bromodomain and extra-terminal (BET) family is a well-known member of bromodomain family. Proteins of this family include BRD2, BRD3, BRD4 and a testis-specific protein, BRDT. BET proteins act as important…
The mitogen-activated protein kinase pathway regulates lots of multiple biological functions. In addition, RAF inhibitors activate the MAPK pathway. Interestingly, the MAPK pathway in turn induces the RAS proteins to…
Apoptosis is a highly regulated program of cell death. Apoptosis occurs in multicellular organisms. Mcl-1 plays an important role in apoptosis. Mechanically, Mcl-1 promotes cell survival by preventing induction of…
FGF family participates in a variety of physiological processes in adult organism including regulation of angiogenesis. FGF acts via high affinity binding to specific receptors (FGFR) in various cells and…
Protein arginine methyltransferases (PRMTs) transfer methyl groups to the arginine residues of histones and other proteins. Fistly, PRMTs add one or two mono-methyl groups to the guanidino nitrogen atoms of…
Axl tyrosine kinase is a putative driver of diverse cellular processes that are critical for the development, growth, and spread of tumors. It is a promising therapeutic target for cancer…
Small molecule drug conjugates (SMDCs) contain three parts: a targeting ligand, a linker, and a drug payload. SMDCs have their own strengths such as manageable synthesis and a non-immunogenic nature.…