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Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

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Acute Leukemia Breast Cancer

CF53, a Potent and Orally Active BET Inhibitor

Louis Gilman March 31, 2019

Bromodomain and extra-terminal (BET) family is a well-known member of bromodomain family. Proteins of this family include BRD2, BRD3, BRD4 and a testis-specific protein, BRDT. BET proteins act as important…

Pancreas Cancer

A Novel and Efficacious RAF Inhibitor RAF709

Louis Gilman March 30, 2019

The mitogen-activated protein kinase pathway regulates lots of multiple biological functions. In addition, RAF inhibitors activate the MAPK pathway. Interestingly, the MAPK pathway in turn induces the RAS proteins to…

Acute Myeloid Leukemia Myeloma

Action Mechanism of a Mcl-1 Inhibitor AZD5991

Louis Gilman March 29, 2019

Apoptosis is a highly regulated program of cell death. Apoptosis occurs in multicellular organisms. Mcl-1 plays an important role in apoptosis. Mechanically, Mcl-1 promotes cell survival by preventing induction of…

Melanoma Ovary Cancer Triple-Negative Breast Cancer

Alofanib, An Allosteric Inhibitor of FGFR2

Louis Gilman March 28, 2019

FGF family participates in a variety of physiological processes in adult organism including regulation of angiogenesis. FGF acts via high affinity binding to specific receptors (FGFR) in various cells and…

Breast Cancer

Role of PRMT7 Probe SGC3027 in Cancer

Louis Gilman March 27, 2019

Protein arginine methyltransferases (PRMTs) transfer methyl groups to the arginine residues of histones and other proteins. Fistly, PRMTs add one or two mono-methyl groups to the guanidino nitrogen atoms of…

Breast Cancer Renal Carcinoma

R916562, a Dual Axl/VEGF-R2 Inhibitor for Cancer Therapy

Louis Gilman March 26, 2019

Axl tyrosine kinase is a putative driver of diverse cellular processes that are critical for the development, growth, and spread of tumors. It is a promising therapeutic target for cancer…

Lung Adenocarcinoma Oral Carcinoma

EC0489, a SMDC for Cancer Therapy

Louis Gilman March 25, 2019

Small molecule drug conjugates (SMDCs) contain three parts: a targeting ligand, a linker, and a drug payload. SMDCs have their own strengths such as manageable synthesis and a non-immunogenic nature.…

Recent Posts

  • Parsaclisib is an Orally Active PI3Kδ Inhibitor for B-cell Malignancies Research
  • Nilotinib is an Orally Active Bcr-Abl Tyrosine Kinase Inhibitor for CML Research
  • Temsirolimus is an mTOR Inhibitor for Kinds of Cancers Research
  • Toripalimab is an Anti-tumor PD-1 Antibody for Nasopharyngeal Carcinoma Research
  • Zanubrutinib is a Selective and Orally Active Btk Inhibitor for Leukemia and Lymphoma Research

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You Missed

B-cell malignancies

Parsaclisib is an Orally Active PI3Kδ Inhibitor for B-cell Malignancies Research

Leukemia

Nilotinib is an Orally Active Bcr-Abl Tyrosine Kinase Inhibitor for CML Research

Acute Lymphoblastic Leukemia Cancer Prostate Cancer

Temsirolimus is an mTOR Inhibitor for Kinds of Cancers Research

Cancer Nasopharyngeal Carcinoma

Toripalimab is an Anti-tumor PD-1 Antibody for Nasopharyngeal Carcinoma Research

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