Sorafenib is an oral multi-kinase inhibitor that inhibits cell proliferation through a strong inhibition of the serine/threonine kinase RAF. Sorafenib was initially approved by the FDA for treatment of metastatic…
TPC2 inhibitor, SG-094 can inhibit hepatocellular carcinoma (HCC) tumor growth by inhibiting two-pore channel 2 (TPC2). TPCs are eukaryotic intracellular voltage-gated and ligand-gated cation-selective ion channels. TPCs are an ancient…
Ferroptosis is an iron-dependent form of regulatory cell death (RCD). Ferroptosis is an oxidative cell death distinct from apoptosis, driven by intense lipid peroxidation. System Xc--GSH-GPX4 is the main ferroptosis…
Toll-like receptors (TLR) are a family of highly conserved pattern recognition receptors. They participate in innate immune responses to pathogen infection. Some of the more than two dozen members of…