SG-094 is a Potent TPC2 Inhibitor for HCC Reasearch
TPC2 inhibitor, SG-094 can inhibit hepatocellular carcinoma (HCC) tumor growth by inhibiting two-pore channel 2 (TPC2). TPCs are eukaryotic intracellular voltage-gated and ligand-gated cation-selective ion channels. TPCs are an ancient family of ion channels. SG-094 exists in the membranes of acidic organelles such as endosomes and lysosomes. These organelles...
FA16 is a Specific Ferroptosis Inducer with Metabolic Stability
Ferroptosis is an iron-dependent form of regulatory cell death (RCD). Ferroptosis is an oxidative cell death distinct from apoptosis, driven by intense lipid peroxidation. System Xc–-GSH-GPX4 is the main ferroptosis inhibition pathway. Among them, system System Xc– is a cystine/glutamic acid antitransporter. It is responsible for the introduction of...
Gardiquimod is a TLR7/8 Agonist and Could Inhibit HIV-1 Infection
Toll-like receptors (TLR) are a family of highly conserved pattern recognition receptors. They participate in innate immune responses to pathogen infection. Some of the more than two dozen members of this class of receptors that include TLR3, TLR7, TLR8, and TLR9 are localized within intracellular vesicles including the endoplasmic...