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Reliable, unbiased and up to date information in cancer research

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Reliable, unbiased and up to date information in cancer research

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Cancer

Trichostatin A (TSA) is a Specific Inhibitor of HDAC Class I/II

Louis Gilman August 31, 2021

Histone deacetylases (HDACs) are enzymes that remove acetyl groups from histone and non-histone proteins. To date, 18 different mammalian HDACs have been identified and divided into four classes: the Class…

Nasopharyngeal Carcinoma

LY294002, a PI3K Inhibitor, is an Autophagy and Apoptosis Inducer

Louis Gilman August 28, 2021

The phosphatidylinositol-3 OH kinase (PI3K)/Akt signaling pathway contributes to cancer survival, apoptosis, and regulating a variety of cellular processes. In particular, Akt serine/threonine kinase plays a critical role in controlling…

Cancer

Staurosporine is an ATP-competitive Inhibitor of Protein Kinases

Louis Gilman August 27, 2021

Protein kinases are enzymes that catalyze protein phosphorylation. Obviously, Protein kinases include many types of kinases, such as  PKC,PKA, c-Fgr and phosphorylase kinase. Thereinto, PKC, PKA and phosphorylase kinase belong…

Cancer Lung Cancer Non-Small Cell Lung Cancer

Rapamycin is a Specific mTOR Inhibitor

Louis Gilman August 25, 2021

mTOR (mammalian target of Rapamycin) is a protein that in humans is encoded by the mTOR gene. mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell…

Cancer

Z-VAD-FMK is a Well-Known pan Caspase Inhibitor

Louis Gilman August 24, 2021

Caspase is a family of cysteine proteases that play essential roles in apoptosis (programmed cell death), necrosis, and inflammation. They are named caspases due to their specific cysteine protease activity-a…

Breast Cancer

HS-131 is a near Infrared Dye Tethered Hsp90 Inhibitor

Louis Gilman August 21, 2021

Hsp90 (heat shock protein 90) is a molecular chaperone protein. Specifically, Hsp90 can help other proteins fold correctly, stabilize proteins, resist heat stress, and contribute to protein degradation. It can…

Cancer

IV-361 is an Orally Active and Selective CDK7 Inhibitor

Louis Gilman August 19, 2021

Cyclin-dependent kinase 7 (CDK7) is a catalytic subunit of CDK activated kinase (CAK). CAK is a kinase complex that catalyzes T-ring phosphorylation and activates a variety of cyclin-related kinases, including…

Mesothelioma

VT-107 is a Pan-TEAD Auto-Palmitoylation Inhibitor

Louis Gilman August 18, 2021

TEA domain (TEAD) transcription factors are sequence-specific DNA binding proteins that regulate transcription. TEAD family transcription factors all contain a DNA-binding domain called a TEA domain. In mammals, TEAD consists…

Acute Myeloid Leukemia

UMB298 is a Selective CBP (P300) Bromodomain Inhibitor

Louis Gilman August 17, 2021

CBP (cyclic AMP response element-binding protein) and P300 (E1A binding protein) are two non-BET bromodomain oncology targets. Additionally, P300 is a paralogue of CBP, and they conduct similar activity. Specifically,…

Breast Cancer

PHPS1 is a Selective Shp2 Inhibitor

Louis Gilman August 14, 2021

SHP2 is a non-receptor protein tyrosine phosphatase (PTP) encoded by the human PTPN11 gene. Particularly, SHP2 contains a PTP catalytic domain and two SH2 domains. SHP2 is a ubiquitous PTP…

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Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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