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Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

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Reliable, unbiased and up to date information in cancer research

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Cancer

Marimastat (BB2516) is a Broad Spectrum and Orally Active Inhibitor of MMPs

Louis Gilman May 31, 2022

Marimastat (BB2516) is a broad spectrum and orally bioavailable inhibitor of MMPs (Matrix metalloproteinases). Marimastat (BB2516) is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood…

uncategorized

Namodenoson (CF-102) is a Selective A3 Adenosine Receptor (A3AR) Agonist

Louis Gilman May 28, 2022

The adenosine A3 receptor (A3AR) comes from the cloning from rat, sheep and human sources. In vitro stimulation of this adenosine receptor subtype shows it inhibits adenylyl cyclase. It also…

Cancer Squamous Carcinoma

Temoporfin is a Second‐generation Photosensitizer for Cancer

Louis Gilman May 26, 2022

Photodynamic therapy (PDT), a phototherapy, is a minimally invasive therapeutic procedure. PDT consists of three essential components-photosensitizer, light and oxygen. None of these is individually toxic, but together they initiate…

Cancer Leukemia Non-Small Cell Lung Cancer

Seliciclib (Roscovitine) is an Orally Active and Selective CDKs Inhibitor

Louis Gilman May 21, 2022

Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose activity depends on a regulatory subunit-a cyclin. Based on the sequence of the kinase domain, CDKs belong to the CMGC group of kinases,…

Cancer ER+ Breast Cancer

Vistusertib (AZD2014) is an ATP Competitive mTOR Inhibitor

Louis Gilman May 19, 2022

mTOR is an atypical serine threonine kinase involved in regulating major cellular functions, such as nutrients sensing, growth, and proliferation. mTOR is part of the multiprotein complexes mTORC1 and mTORC2.…

Cancer

Epoxomicin is a Selective and Irreversible Inhibitor of Proteasome

Louis Gilman May 17, 2022

Epoxomicin (BU-4061T) is a potent, selective and irreversible proteasome inhibitor. Epoxomicin can cross the blood-brain barrier and has strongly antitumor and anti-inflammatory activity. Proteasome is a 700 kDa, cylindrical-shaped multicatalytic…

Acute Myeloid Leukemia Cancer

5-Azacytidine, a Nucleoside Analogue of Cytidine, Inhibits DNA Methylation

Louis Gilman May 12, 2022

In the mammalian genome, DNA methylation is an epigenetic mechanism involving the transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA methylation regulates…

Cancer Colorectal Cancer

Pimasertib is a Highly Selective and ATP non-Competitive Allosteric Inhibitor of MEK1/2

Louis Gilman May 11, 2022

The RAS/RAF/MEK/MAPK and the PTEN/PI3K/AKT/mTOR pathways are key regulators of proliferation and survival in human cancer cells. RAF is a serine/threonine kinase that activates downstream signals in response to activated…

Breast Cancer

Epothilone B is a Microtubule Stabilizer

Louis Gilman May 9, 2022

Microtubules are polymers of tubulin, which is one of several members of a small family of globular proteins. The tubulin superfamily includes five distinct families, the α-, β-, γ-, δ-,…

Cancer

Bisantrene, an Antitumor Drug, Targets Eukaryotic Type II Topoisomerases

Louis Gilman May 7, 2022

ImprotDNA topoisomerases are enzymes that disentangle the topological problems that arise in double-stranded DNA. Type II topoisomerases are ubiquitous enzymes that play essential roles in a number of fundamental DNA…

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JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

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OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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