DC_AC50 is a Dual inhibitor of Atox1 and CCS (Copper Chaperones)
Copper is a redox-active transition metal critical for most living organisms. At the same time, it serves as a catalytic cofactor for enzymes. Those enzymes play roles in antioxidant defense, iron homeostasis, cellular respiration, and a variety of biochemical processes. However, intracellular free copper may exhibit toxic side effects....
HLI373 is an Efficacious Hdm2 Inhibitor, with Antimalarial Activity
Hdm2 is an ubiquitin-protein ligase. Hdm2 suppresses the transcriptional activity of the tumor suppressor p53 and promotes its degradation. HLI373 is an efficacious Hdm2 inhibitor. HLI373 is effective in inducing apoptosis of several tumor cell lines that are sensitive to DNA-damaging agents. These results suggest that HLI373 could serve...