PAI-1 (plasminogen activator inhibitor-1, also known as SERPINE1) is a member of the serine protease inhibitor (SERPIN) family and is the primary inhibitor of two major mammalian plasminogen activators (urinary…
Copper is a redox-active transition metal critical for most living organisms. At the same time, it serves as a catalytic cofactor for enzymes. Those enzymes play roles in antioxidant defense,…
Hdm2 is an ubiquitin-protein ligase. Hdm2 suppresses the transcriptional activity of the tumor suppressor p53 and promotes its degradation. HLI373 is an efficacious Hdm2 inhibitor. HLI373 is effective in inducing…