Rucaparib is a PARP Inhibitor
PARP is a family of proteins involved in many cellular processes, such as DNA repair, genomic stability, and programmed cell death. At least 18 members of the PARP family are encoded by different genes and have homology in conserved catalytic domains. Specifically, PARPs play an important role in various...
VT-107 is a Pan-TEAD Auto-Palmitoylation Inhibitor
TEA domain (TEAD) transcription factors are sequence-specific DNA binding proteins that regulate transcription. TEAD family transcription factors all contain a DNA-binding domain called a TEA domain. In mammals, TEAD consists of four members (TEAD1-TEAD4), and they share high degree of sequence homology and highly similar structural domain architectures. Besides,...