Category: Skin Cancer

MK-2206 is an Orally Active and Selective Allosteric Akt Inhibitor

Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma arising from the epithelium lining of the posterior nasopharynx. In a word, NPC causes very serious health problems in these areas. NPC is highly sensitive to radiation and chemotherapy. However, even with combined radiation and chemotherapy treatment, the prognosis for the...

BDP9066 is a Selective MRCK Inhibitor for Skin Cancer Treatment

The myotonic dystrophy-related Cdc42-binding kinases MRCKα and MRCKβ contribute to the regulation of actin-myosin cytoskeleton organization and dynamics, acting in concert with the Rho-associated coiled-coil kinases ROCK1 and ROCK2. A study from Mathieu Unbekandt discovered and identified azaindole compounds BDP8900 and BDP9066 as potent and selective MRCK inhibitors. Both...