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Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

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Cancer

MS170 is a PROTAC AKT Degrader

Louis Gilman February 27, 2022

The alternative name of serine/threonine kinase AKT is protein kinase B (PKB). Three closely related genes in humans: AKT1 (PKB-α), AKT2 (PKB-β), and AKT3 (PKB-γ) encode PKB. AKT is an…

Breast Cancer Glioblastoma Lung Cancer Melanoma Non-Small Cell Lung Cancer Prostate Cancer

Indoximod, An Immunometabolic Adjuvant, is an IDO Pathway Inhibitor

Louis Gilman February 25, 2022

Indoleamine 2,3-dioxygenase (IDO) is an enzyme of interest in immuno-oncology. It has immunosuppressive effects that result from its role in tryptophan catabolism. IDO1 catalyzes the initial rate-limiting step in the…

Breast Cancer Colorectal Cancer Melanoma

Lomeguatrib is a O6-Methylguanine-DNA Methyltransferase (MGMT) Inhibitor

Louis Gilman February 19, 2022

O6-alkylguanine DNA alkyltransferase (also known as AGT, MGMT or AGAT) is a protein that in humans is encoded by the O6-methylguanine DNA methyltransferase (MGMT) gene. MGMT repairs the naturally occurring…

Neuroblastoma

VAL-083 Creates DNA N7 Methylation with Antitumor Activity

Louis Gilman February 17, 2022

Glioblastoma (GBM) is one of the most difficult tumors. Many new agents fail to cross the blood-brain barrier (BBB) and it has intrinsic drug resistance. VAL-083 is an alkylating agent…

Cancer

Hesperadin is an ATP Competitive Indolinone Inhibitor of Aurora A and B

Louis Gilman February 16, 2022

Aurora kinases (AURK) are a group of serine/threonine kinases. And they participate in the cellular division through the regulation of chromatid segregation. what's more, AURK has three subclasses: AURKA, AURKB,…

Cancer

PFM39 is a Selective MRE11 Exonuclease Inhibitor

Louis Gilman February 12, 2022

Double-strand break repair protein MRE11 is an enzyme that in humans is encoded by the MRE11 gene. The MRE11/Rad50/NBS1 (MRN) complex maintains genomic stability by bridging DNA ends, and initiating…

Acute Myeloid Leukemia Leukemia

HM43239 is an Orally Active and Selective FLT3 Inhibitor

Louis Gilman February 7, 2022

Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with an incidence of over 20 000 cases per year in the United States alone. Large chromosomal translocations,…

Lung Cancer Non-Small Cell Lung Cancer

GS-493 is a Selective Protein Tyrosine Phosphatase SHP2 (PTPN11) Inhibitor

Louis Gilman February 3, 2022

The protein tyrosine phosphatase SHP2 (also called SH-PTP2, Syp, PTP1D, and PT-P2C) is a ubiquitously expressed 68 kDa non-receptor PTP. In the inactive state, the SH2 domains of SHP2 auto-inhibit the…

Recent Posts

  • BI 7446 is a STING Agonist for Immuno-oncology Research
  • JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research
  • OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research
  • INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research
  • Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

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