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Reliable, unbiased and up to date information in cancer research

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Reliable, unbiased and up to date information in cancer research

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Pancreas Cancer

PKI-166 is a Selective and Orally Bioavailable EGFR Autophosphorylation Inhibitor

Louis Gilman January 30, 2020

Human pancreatic cancer cells can secrete the proangiogenic molecules, such as VEGF, IL-8, and basic fibroblast growth factor. VEGF is the major proangiogenic factor in most types of human cancer.…

Breast Cancer

BCI-215 is a Tumor Cell-Selective DUSP-MKP Inhibitor

Louis Gilman January 28, 2020

Mitogen-activated protein kinase phosphatases (MKPs) belongs to the dual-specificity phosphatase (DUSP) family. DUSP-MKPs dephosphorylate and inactivate the MAPKs extracellular signal-regulated kinase (ERK), JNK/SAPK, and p38 on tyrosine and threonine residues.…

Cancer

PF-573228 is a Potent and Selective FAK Inhibitor

Louis Gilman January 26, 2020

Focal adhesion kinase (FAK) is a member of a family of non-receptor protein-tyrosine kinases. The FAK4 family kinases (which include FAK and Pyk2) regulate integrin and growth factor signaling pathways…

Acute Myeloid Leukemia Leukemia

A-366 is a Potent Histone Methyltransferase G9a Inhibitor

Louis Gilman January 23, 2020

Epigenetic alterations to the genome take place via modifications to the DNA or histones. Meanwhile, those modifications lead to changes in gene expression. Generally, histone lysine methylation is a prominent…

Myeloma

AZD4547 is a Potent FGFR Family Inhibitor

Louis Gilman January 21, 2020

Fibroblast growth factors (FGF) and their receptors play important roles in multiple biologic processes, such as tissue repair, hematopoiesis, angiogenesis, and embryonic development. The FGFR family mainly comprises 4 main…

Cancer

CGP52411 is an Orally Active and ATP-Competitive EGFR Inhibitor

Louis Gilman January 19, 2020

The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that mediates the response of cells to EGF and transforming growth factor α. Deregulated signal transduction via the EGFR family…

Acute Myeloid Leukemia Liver Cancer Lung Cancer Non-Small Cell Lung Cancer

PI-103 is a Potent PI3K and mTOR Inhibitor

Louis Gilman January 17, 2020

The phosphatidylinositide 3-kinase family possesses 15 members. those members consist of four distinct classes as a basis on their structure and biological properties. As we all know, this highly conserved…

Breast Cancer Cervical Cancer Endometrial Cancer Head and Neck Cancer Ovary Cancer

COTI-2 is an Orally Available Mutant p53 Activator

Louis Gilman January 16, 2020

TP53 (p53) is the single most frequently altered gene in human cancers, with mutations being present in approximately 50% of all invasive tumors. Besides, p53 is mutated in at least…

Hematological Malignancies

CC-223 is an Orally Bioavailable mTOR Kinase Inhibitor

Louis Gilman January 14, 2020

mTOR is a serine/threonine kinase that regulates cell growth, metabolism, proliferation, and survival. mTORC1 is a master regulator of cell growth and metabolism. mTORC1 positively regulates cell growth and proliferation.…

Neuroblastoma

GPP78 is a Nampt Inhibitor and an Autophagy Inducer

Louis Gilman January 12, 2020

Nicotinamide phosphoribosyltransferase (NAMPT) is an enzyme that catalyzes the synthesis of nicotinamide mononucleotide (NMN) from nicotinamide (NM) and PRPP. Therefore, NAMPT plays an important role in the cyclic biosynthetic pathway…

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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