J-113397 is a Potent and Selective ORL1 Receptor Antagonist
The opioid receptor-like (ORL1) receptor, is also known as the nociceptin opioid peptide receptor (NOP). The ORL1 receptor belongs to the opioid subfamily of G protein-coupled receptors whose natural ligand is the 17 amino acid neuropeptide. J-113397 is an opioid agent which was the first potent and highly selective...
ACY-1083, a Highly Selective HDAC6 Inhibitor, Reverses Chemotherapy-induced Peripheral Neuropathy
Nerves carry messages from the brain to the rest of the body. Peripheral neuropathy occurs when the peripheral nervous system is damaged. Chemotherapy-induced peripheral neuropathy is one of the most commonly and widely reported adverse side effects of cancer treatment. The symptoms of cemotherapy-induced peripheral neuropathy include pain, numbness, tingling,...