Androgen receptor (AR), is a member of the nuclear hormone receptor superfamily. AR is involved in sex development, reproductive system function, and androgen regulation. It regulates a variety of cellular events,…
v-Raf murine sarcoma viral oncogene homolog B (BRAF) is the part of the mitogen-activated protein kinase (MAPK) signaling pathway. BRAF was first discovered in 2002. The discovery of BRAF mutations…
ROS1 (c-ros oncogene 1) is a receptor tyrosine kinase encoded by the gene ROS1. Importantly, ROS1 is a proto-oncogene and highly expressed in a variety of tumor cell lines, belonging…
The phosphatidylinositol 3-kinase (PI3K) signaling pathway regulates a number of crucial cellular processes, including growth, survival, angiogenesis, migration and metabolism. The PI3K family consists of four isoforms: Class I, Class…
Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause that occurs primarily in older adults. In addition, IPF is characterized by substantial…
Bruton tyrosine kinase (Btk), a non-receptor kinase, is a member of the Tec family kinases. Btk is exists in B cells and myeloid cells. Btk has a carboxy-terminal catalytic domain…
MicroRNAs (miRNAs) are a class of short noncoding RNAs that negatively regulate gene expression. In addition, more than 2,500 mature miRNAs in the human genome and miRNAs can regulate approximately…
HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more…
Hsp90 (heat shock protein 90) is a chaperone protein that helps other proteins fold correctly, stabilizes proteins against heat stress, and aids in protein degradation. Besides, it stabilizes many proteins…
PAI-1 (plasminogen activator inhibitor-1, also known as SERPINE1) is a member of the serine protease inhibitor (SERPIN) family and is the primary inhibitor of two major mammalian plasminogen activators (urinary…