Category: Colon Cancer

Tetrac is a Thyrointegrin Receptor Antagonist

In the angiogenesis process, integrins are members of a family of cell surface transmembrane receptors. They play a critical role particularly in blood vessel formation and the local release of vascular growth factors. Thyroid hormones such as T4 and T3 promote angiogenesis and tumor cell proliferation via integrin αvβ3...

CB-1158 is a Potent and Orally Active Arginase Inhibitor

Myeloid cells are an abundant leukocyte in many types of tumors and contribute to immune evasion. The major populations of tumor-infiltrating myeloid cells include tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and granulocytes. A feature common to all of these immunosuppressive cells is their expression of the enzyme arginase...

Z-LEHD-FMK is a Selective and Irreversible Inhibitor of Caspase-9

TRAIL is a potent inducer of apoptosis of transformed and cancer cells but not of most normal cells. TRAIL induces apoptotic death on binding to either of two proapoptotic TRAIL receptors, TRAIL R1 or TRAIL R2. Moreover, normal cells may resistant to TRAIL because of expressing higher levels of...

HM03 is a Potent and Selective HSPA5 Inhibitor

Heat shock protein 70 (HSP70) are chaperone proteins that protect proteins from stress and promote nascent polypeptide folding. They exist in both prokaryotic and eukaryotic organisms. The stress-inducible HSP70 is an emerging cancer target that directly inhibits apoptosis. Administration of the inhibitors for HSP90 induces the expression of HSP70....

TP3011 is a Potent Topoisomerase-1 Inhibitor with Anti-tumor Effect

Topoisomerases are proteins that cut the DNA backbone. Especially, topoisomerases let the cut ends twist past each other to a more relaxed configuration. Moreover, topoisomerases reseal the phosphodiester bonds in the backbone to again form an intact double helix. DNA topoisomerases I and II present in cells acts through...

NU1025 is a Potent PARP Inhibitor with Anti-Cancer and Neuroprotective Activity

Excessive glutamate release, Ca++ overload, free radical generation, poly (ADP-ribose) polymerase (PARP) overactivation are the main events of neuronal cell death in ischemic stroke. Besides, stroke is a third leading cause of death after heart diseases and cancer and a major cause of disabilities throughout the world. Moreover, excessive...