CXCRs (CXC chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine family. There are seven CXC chemokine receptors in mammals, named CXCR1…
Acute myeloid leukemia (AML) is a disease along with poor prognosis. AML results from rapid proliferation of immature myeloid cells in the bone marrow. CD123 (IL3RA) is expressed in the…
Fms-related tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase expresses on hematopoietic cells. However, FLT3 plays a critical role in both normal and malignant hematopoiesis. According to existing research…
FLT3 (Fms-like tyrosine kinase 3, CD135) is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Besides, FLT3 is important for the normal development of stem cells and…
KIT receptors belong to the Class III receptor tyrosine kinase (RTK) family, which also includes PDGFRA (platelet-derived growth factor receptor A) and CSF1R (colony stimulating factor 1 receptor). Stem cell…
Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. unexpectedly, the members of the type I and type II cytokine…
Acute Myeloid Leukemia (AML) is a disease of the bone marrow, a disorder of hematopoietic stem cells due to genetic alterations in blood cell precursors resulting in overproduction of neoplastic…
Isocitrate dehydrogenase (IDH) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate. Firstly, IDH exists in three isoforms in humans: IDH3 catalyzes the citric acid cycle while converting NAD+…
Acute myeloid leukemia (AML) is a group of malignant diseases of the hematopoietic system. And, AML occurs as the result of mutations in hematopoietic stem/progenitor cells. Despite advances in treatment,…
TTT-3002, a tyrosine kinase inhibitor is one of the most potent FLT3 inhibitors. FLT3 (Fms-like tyrosine kinase 3, CD135) is a cytokine receptor that belongs to the receptor tyrosine kinase…