Icotinib is a Potent EGFR Inhibitor for Non-small Cell Lung Cancer Research
Lung cancer is the uncontrolled proliferation of cells lining the air passages and tissues of the lungs. It is the second most common cancer in both men and women. It…
Lung cancer is the uncontrolled proliferation of cells lining the air passages and tissues of the lungs. It is the second most common cancer in both men and women. It…
The epidermal growth factor receptor (EGFR) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands. The EGFR…
Belonging to a tyrosine kinase family, TRK receptors (TRKA/B/C)—are significantly involved in embryonic neuronal development and differentiation. Moreover, TRKA/B/C play specialized roles in controlling vital functions like pain, movement, mood,…
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein. And it is a receptor for members of the epidermal growth factor family (EGF family) of…
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase of insulin receptor superfamily. In addition, ALK is relevant with solid and hematologic cancers, such as none small cell lung cancers…
On November 16, 2023, the U.S. Food and Drug Administration has approved Repotrectinib. Repotrectinib is indicated for the treatment of adult patients with ROS1-positive locally advanced or metastatic non-small cell…
Microtubules are a component of the cytoskeleton. Microtubules are found in eukaryotic cells and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin.…
EGFR-mutated (EGFRm+) non-small cell lung cancer (NSCLC) is a major clinical problem. Tyrosine kinase inhibitors (TKIs) have precision therapeutic implications for advanced NSCLC. However, common EGFR mutations, such as EGFRL858R,…
The EGFR family of receptor tyrosine kinases (RTK) comprises four distinct receptors: the EGFR (also known as ErbB-1/HER1), ErbB-2 (neu, HER2), ErbB-3 (HER3) and ErbB-4 (HER4). These structurally related receptors…
ATR kinase is a key component of the DNA damage response pathway. Additionally, it plays a critical role in maintaining genome stability. Ceralasertib (AZD6738) is a potent inhibitor of ATR…