As more active compounds found in Triple-negative breast cancer (TNBC), this kind of malignant tumor has received more and more attention. Our previous article “IITZ-01 as a Potent Lysosomotropic Autophagy…
Immunomodulatory drugs (IMiDs), including Thalidomide and its analogues, which possess pleiotropic anti-myeloma properties. These properties include immune-modulation, anti-angiogenic, anti-inflammatory and anti-proliferative effects. Thalidomide is an immunomodulatory drug, which is used…
Recently, National Cancer Institute has reported a novel inhibitor TAK-981 for SUMOylation enzymatic cascade. This inhibitor showed potential immune-activating and antineoplastic activities. Firstly, TAK-981 targets and covalently binds to the…
To develop small molecules that modulate protein-protein interactions (PPIs) displays a significant therapeutic potential. However, rational design of small molecule enhancers of PPIs remains elusive. A study from Kyle R.…
Protein kinases inhibition is a common therapeutic strategy for many diseases, including cancers, inflammatory diseases, diabetes and neurodegenerative disorders. The Ser-/Thr-specific kinase Akt is also known as protein kinase B.…
Prostate cancer arises as an androgen driven disease. Therefore the mainstay of systemic therapy for patients with advanced disease is androgen deprivation therapy. Despite of significant responses, nearly all patients…
Leukemia is a kind of blood cancer, begins in the bone marrow and results in abnormal blood cells. It severely affects the patients. The need for more drugs with fewer…
Microtubules are part of the mitotic spindle, the complex and dynamic structure that mediates chromosome separation during mitosis. Therefore, microtubules are a proven target in cancer treatment. There have been…
(E)-AG 99 is a potent and reversible EGFR inhibitor and has potential treatment Bladder cancer. Bladder cancer (BC) is one of common malignancies worldwide. Bladder cancer is any of several…
Protein arginine methylation, a common post-translational modification, involves in numerous cellular processes including transcription, DNA repair, mRNA splicing and signal transduction. Protein arginine methyltransferases (PRMTs) catalyze arginine methylation on both…