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Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

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Reliable, unbiased and up to date information in cancer research

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Triple-Negative Breast Cancer

SLLN-15 Activates Autophagy in Triple-Negative Breast Cancer (TNBC)

Louis Gilman April 30, 2019

As more active compounds found in Triple-negative breast cancer (TNBC), this kind of malignant tumor has received more and more attention. Our previous article “IITZ-01 as a Potent Lysosomotropic Autophagy…

Myeloma PROTAC

TD-428 is a Highly Specific BRD4 Degrader

Louis Gilman April 29, 2019

Immunomodulatory drugs (IMiDs), including Thalidomide and its analogues, which possess pleiotropic anti-myeloma properties. These properties include immune-modulation, anti-angiogenic, anti-inflammatory and anti-proliferative effects. Thalidomide is an immunomodulatory drug, which is used…

Lymphoma

TAK-981, an Inhibitor For SUMOylation Enzymatic Cascade with Antineoplastic Activities

Louis Gilman April 28, 2019

Recently, National Cancer Institute has reported a novel inhibitor TAK-981 for SUMOylation enzymatic cascade. This inhibitor showed potential immune-activating and antineoplastic activities. Firstly, TAK-981 targets and covalently binds to the…

Cancer

NRX-252262, an Enhancer of β-catenin:β-TrCP Interaction

Louis Gilman April 27, 2019

To develop small molecules that modulate protein-protein interactions (PPIs) displays a significant therapeutic potential. However, rational design of small molecule enhancers of PPIs remains elusive. A study from Kyle R.…

Cancer

Borussertib, a Covalent-Allosteric Akt Inhibitor

Louis Gilman April 26, 2019

Protein kinases inhibition is a common therapeutic strategy for many diseases, including cancers, inflammatory diseases, diabetes and neurodegenerative disorders. The Ser-/Thr-specific kinase Akt is also known as protein kinase B.…

Castration Resistant Prostate Cancer

Y06137 is a Selective BET Inhibitor for Treatment of CRPC

Louis Gilman April 25, 2019

Prostate cancer arises as an androgen driven disease. Therefore the mainstay of systemic therapy for patients with advanced disease is androgen deprivation therapy. Despite of significant responses, nearly all patients…

Leukemia

BTR-1 Induces Cell Growth Inhibition Followed by Apoptosis

Louis Gilman April 24, 2019

Leukemia is a kind of blood cancer, begins in the bone marrow and results in abnormal blood cells. It severely affects the patients. The need for more drugs with fewer…

Colon Cancer Gliocytoma

Cevipabulin (TTI-237) is a Microtubule-Active Antitumor Compound

Louis Gilman April 23, 2019

Microtubules are part of the mitotic spindle, the complex and dynamic structure that mediates chromosome separation during mitosis. Therefore, microtubules are a proven target in cancer treatment. There have been…

Bladder Cancer

A Potent and Reversible EGFR Inhibitor (E)-AG 99

Louis Gilman April 22, 2019

(E)-AG 99 is a potent and reversible EGFR inhibitor and has potential treatment Bladder cancer. Bladder cancer (BC) is one of common malignancies worldwide. Bladder cancer is any of several…

Non-Small Cell Lung Cancer Small Cell Lung Cancer

JNJ-64619178 is a Selective PRMT5 Inhibitor with Potent Activity In Lung Cancer

Louis Gilman April 21, 2019

Protein arginine methylation, a common post-translational modification, involves in numerous cellular processes including transcription, DNA repair, mRNA splicing and signal transduction. Protein arginine methyltransferases (PRMTs) catalyze arginine methylation on both…

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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